Easy Way to Remember Top 200 Drugs

Top 200 Drugs To Memorize

Top 200 Drugs

Top 200 Drugs To Memorize in Your Daily Clinical Practice

In this Article you will Read About Top & Most Common Prescribed Drugs:

  1. Cardiovascular Drugs 💊
  2. CNS Drugs 💊
  3. Benzodiazepines Drugs 💊
  4. Dopamine Agonist Drugs 💊
  5. Dementia and Alzheimer Disease Drugs 💊
  6. Anti-Diabetic Drugs 💊
  7. Antihyperlipidemic Agents Drugs 💊
  8. Musculoskeletal Drugs 💊
  9. Gastrointestinal Drugs 💊
  10. Respiratory Drugs 💊
  11. Antiglaucoma Drugs 💊
  12. Antimicrobial Drugs 💊
  13. Hormone Treatment Drugs 💊
  14. Anticoagulant Drugs 💊
  15. Miscellaneous Drugs 💊
  16. Hypothyroidism Drugs 💊
  17. Vitamins  💊
  18. Attention deficit hyperactivity disorder Drugs 💊
  19. Anti-epileptics Drugs 💊
  20. Anorexiant Drugs 💊
  21. Anti-manic Drugs 💊

Top 200 Drugs

Over the past few decades, the health care needs of our population changed along with the role of pharmacists.

Historically, the pharmacists' role in healthcare was centred on dispensing medications. In addition, they have to ensure the accurate delivery of medications to patients.

Today pharmacists are an integral part of our health care team.

They are also considered the most accessible health care professionals.

Additionally, this approachability enables them to perform their pharmacists' patient care process (PPCP).

This process contains items such as collect, access, plan, implement and follow-up.

It's done to monitor and evaluate the appropriateness and effectiveness of medications and to obtain patient feedback.

Additionally, pharmacists advise other health professionals concerning medication therapy decisions.

Moreover, inform them about the composition of drugs, their physicochemical and biological properties.


What is Pharmacist Role?

Pharmacists also ensure the drug purity, efficacy, their interactions and side effects.

To deliver excellent pharmacy services to patients, pharmacists need to have complete knowledge of commonly prescribed drugs.

In 2014, the total number of prescriptions dispensed was approximately 4.325 billion.

Out of which the top 200 most prescribed drugs accounted for approximately 2.87 billion.

The top 200 drugs represent 66.6% (2/3) of total prescriptions filled.


Top 200 drugs according to the targeted system:

The lists contain many blockbuster drugs of the last 10 to 15 years, such as atorvastatin, simvastatin, etc.

The most prescribed drugs based on systems were cardiovascular (49), central nervous system (42), endocrine (30) and musculoskeletal (19).

They accounted for approximately 140 drugs (70%) of top 200 most prescribed drugs.

Top 200 drugs


Top 200 drugs and their Categories:

Top Cardiovascular drugs

They are agents that affect the function of the heart and blood vessels. They are considered as one of the most widely used  drugs in medicine.

The term heart disease describes a  wide range of conditions that affect the heart. Diseases under the heart disease umbrella include blood vessel diseases, such as coronary artery disease.

In addition, the heart rhythm problems (arrhythmias); and congenital heart defects.

Moreover, the diseases that affect heart muscle, valves or rhythm are considered forms of heart disease. There is also another term used "cardiovascular disease."

Cardiovascular disease generally refers to conditions that involve narrowed or blocked blood vessels that can lead to a heart attack, chest pain (angina) or stroke.

Treatment for heart disease includes medication, lifestyle changes and surgery or procedures.

Heart medication is used to treat heart conditions, manage the symptoms of heart disease, and reduce the risk of future heart events.


Examples of heart disorders in which drugs in the top 200 list:

  • Hypertension (high blood pressure)
  • Angina pectoris (chest pain resulting from inadequate blood flow through the coronary arteries to the heart muscle)
  • Heart failure (inadequate output of the heart muscle in relation to the needs of the rest of the body)
  • Arrhythmias (disturbances of cardiac rhythm).

Common categories & mechanisms of CVS Drugs

ACE Inhibitors

ACE (angiotensin-converting enzyme) Inhibitors are   antihypertensive medications. the hypotensive effect of ACE inhibitors are due to

  • Block the conversion of angiotensin I to angiotensin II
  • Inhibits the degradation of bradykinin

     Calcium Channel Blocker

Calcium channel blockers, also called calcium antagonists, prevent calcium from entering cells of the heart and blood vessel walls.

This is resulting in  reducing  electrical conduction within the heart, decrease the force of contraction of the muscle cells.

In addition to dilating arteries. As a result, the blood vessels relax and the heart muscle receives more oxygenated blood.

Uses of calcium channel blockers

to prevent, treat or improve symptoms in a variety of conditions, such as:

  • High blood pressure
  • Coronary artery disease
  • Chest pain (angina)
  • Irregular heartbeats (arrhythmia)
  • Some circulatory conditions, such as Raynaud's disease

  There are 3 classes of CCBs

  • Dihydropyridines
  • Phenylalkylamines
  • benzothiazepines

   Beta blocker

Beta blockers, also known as beta-adrenergic blocking agents, are a class of drugs that works by blocking the neurotransmitters norepinephrine and epinephrine from binding to receptors.

When the neurotransmitters are prevented from binding to the receptors, it in turn causes the effects of adrenaline (epinephrine) to be blocked. This action allows the heart to relax and beat more slowly thereby reducing the amount of blood that the heart must pump. Over time, this action improves the pumping mechanism of the heart.

Uses for beta blockers

There are several types of beta blocker, and each one has its own characteristics. They can be used to prevent, treat or improve symptoms in a variety of conditions, such as:

  • High blood pressure
  • Irregular heart rhythm (arrhythmia)
  • Heart failure
  • Chest pain (angina)
  • Heart attacks
  • Migraine
  • Certain types of tremors
  • an overactive thyroid (hyperthyroidism)
  • anxiety conditions
  • glaucoma – as eye drops

     Diuretic

  • Diuretic drugs increase urine output by the kidney (i.e., promote diuresis).
  • Most diuretics produce diuresis by inhibiting the reabsorption of sodium at different segments of the renal tubular system.
  • That helps to relieve the heart's workload and decreases the buildup of fluid in the lungs and other parts of the body, such as the ankles and legs.
  • There are three types of diuretics: thiazide, loop and potassium-sparing.
  • Each type affects a different part of  kidneys and may have different uses, side effects and precautions

Alpha-2-agonist

  • They are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors.
  • The alpha-adrenergic receptor has two subclasses α1 and α2. Alpha 2 receptors are associated with sympatholytic properties.
  • In addition, α Adrenergic agonists have the opposite function of alpha blockers.
  • The activation of α2 inhibits the enzyme adenylate cyclase.
  • Inactivation of adenylate cyclase in turn leads to the inactivation of the secondary messenger cyclic adenosine monophosphate and induces smooth muscle and blood vessel constriction.

     Angiotensin II  receptor blocker (ARB)

  • Block the action of angiotensin II by preventing angiotensin II from binding to angiotensin II receptors on the muscles surrounding blood vessels.
  • As a result, blood vessels enlarge (dilate) and blood pressure is reduced.

     Vasodilator

  • Relax the smooth muscle in blood vessels, which causes the vessels to dilate.
  • Dilation of arterial (resistance) vessels leads to a reduction in systemic vascular resistance, which leads to a fall in arterial blood pressure.

Alpha-1-Blocker

  • They work by keeping the hormone norepinephrine from tightening the muscles in the walls of arteries and veins.
  • This causes the vessels to remain open and relaxed and so improves blood flow and lowers blood pressure.


Top CNS Drugs

There are many different types of drugs that work on the CNS, including  anesthetics, anticonvulsants.

In addition, antiemetics, antiparkinson agents, CNS stimulants, muscle relaxants, narcotic analgesics (pain relievers).

Moreover, the nonnarcotic analgesics (such as acetaminophen and NSAIDs), and sedatives.

Analgesic non opioid

Analgesics are medicines that are used to relieve pain. They are also known as painkillers or pain relievers.

Technically, the term analgesic refers to a medication that provides relief from pain without putting you to sleep or making you lose consciousness.


The most common groups of pain killers

  • non-opioid analgesics non steroidal anti-inflammatory drugs (NSAIDs) and paracetamol
  • opioids (narcotics)

Opioid

  • Act on receptors located on neuronal cell membranes.
  • The presynaptic action of opioids to inhibit neurotransmitter release is considered to be their major effect in the nervous system.

NSAID

  • They block the COX enzymes and reduce prostaglandins throughout the body.
  • As a consequence, ongoing inflammation, pain, and fever are reduced.

Top 200 Drugs

Antidepressants

Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain.

Chemical imbalances may be responsible for changes in mood and behavior.

Types of antidepressants

Certain brain chemicals called neurotransmitters are associated with depression — particularly serotonin , norepinephrine  and dopamine.

Most antidepressants relieve depression by affecting these neurotransmitters. Each type (class) of antidepressant affects these neurotransmitters in slightly different ways.

Many types of antidepressant medications are available to treat depression, including:

  • Selective serotonin reuptake inhibitors (SSRIs).
  • Serotonin and norepinephrine reuptake inhibitors (SNRIs).
  • Atypical antidepressants.
  • Tricyclic antidepressants.
  • Monoamine oxidase inhibitors (MAOIs).
  • Other medications.

 Selective serotonin reuptake inhibitors (SSRI)

SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption into the presynaptic cell.

They increase the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor.

Serotonin and norepinephrine reuptake inhibitors SNRI

It's believed that SNRIs help treats depression by keeping up the levels of serotonin and norepinephrine in the brain.

They do this by stopping them from going back into the cells that released them

Dopamine/norepinephrine reuptake inhibitor

Act as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine. This is by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT).

They used as antidepressant drugs and in smoking cessation.

Alpha-2- agonist

They enhance the release of norepinephrine and serotonin through blockage of presynaptic alpha-2 adrenergic receptors.

Additionally, it blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent histamine h1 receptor antagonist.

It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.


Commonly Used Benzodiazepines

Sedative- hypnotic- Anxiolytic

The sedative-hypnotics belong to a chemically heterogeneous class of drugs almost all of which produce dose-dependent CNS depressant effects.

A major subgroup is the benzodiazepines, but representatives of other subgroups, including barbiturates.

Newer drugs with distinctive characteristics include the anxiolytic buspirone, several widely used hypnotics (zolpidem, zaleplon, eszopiclone), and melatonin agonists and orexin antagonists, novel drugs used in sleep disorders.

Benzodiazepine

They enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor.

This result  in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties.


Commonly Used Dopamine Agonist

Anti-parkinsonian drugs

The drug treatment of Parkinson's disease has progressed through 3 main stages:

Firstly, the use of anticholinergic drugs and amantadine.

Secondly, the introduction of levodopa and its association with peripheral decarboxylase inhibitors.

Finally the use of direct acting dopamine agonist drugs.

Dopamine agonist

  • Activate receptors in the brain that produce dopamine, a chemical that helps regulate movement and mood

Top 200 Drugs


Drugs for Dementia and Alzheimer Disease

Dementia, including Alzheimer disease, has been found to involve a number of systems in the brain.

There is evidence for a decrease in markers of cholinergic neuron activity and for changes in brain glutamate, dopamine, norepinephrine, serotonin, and somatostatin.

Eventually, cholinergic neurons die or are destroyed. Treatment has focused on increasing the amount of acetylcholine in the synapse by inhibiting the breakdown of acetylcholine.

Acetylcholinesterase inhibitor

  • Inhibit the acetylcholinesterase enzyme from breaking down acetylcholine.
  • Thereby increasing both the level and duration of action of the neurotransmitter acetylcholine

N-Methyl-D-aspartate receptor NMDA receptor antagonist

  • A dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is hypothesised to be involved in the etiology of Alzheimer's disease. Targeting the glutamatergic system, specifically NMDA receptors, offers a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system.
  • Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors.


Commonly Used Anti-Diabetic Drugs

Drugs used in diabetes treat diabetes mellitus by lowering the glucose level in the blood.

Insulin

Insulin is a protein hormone that is used as a medication to treat high blood glucose. This includes in diabetes mellitus type 1, diabetes mellitus type 2, gestational diabetes, and complications of diabetes.

SGLT2 inhibitor

Sodium-glucose co-transporter-2 inhibitors work by inhibiting SGLT2. This is to prevent reabsorption of glucose and facilitate its excretion in urine.

Sulfonylurea

These drugs exert their hypoglycaemic effects by stimulating insulin secretion from the pancreatic beta-cell

Biguanide

Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose.

It also improves insulin sensitivity by increasing peripheral glucose uptake and utilization.


DPP-4 inhibitor

It increases incretin levels (GLP-1 and GIP).

It inhibits glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.

Thiazolidinedione

Work on lowering  the  insulin resistance, which is the underlying problem for many people with type 2 diabetes.

Glucagon-like peptide 1 receptor agonist

Affect glucose control through several mechanisms.

Such as enhancement of glucose-dependent insulin secretion, slowing gastric emptying, and reduction of postprandial glucagon and food intake.


Commonly hyperlipidemia Agents

Antihyperlipidemic agents promote the reduction of lipid levels in the blood.

Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein (LDL) cholesterol.

Some reduce triglyceride levels, and some help raise the high-density lipoprotein (HDL) cholesterol.

By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease.

HMG-CoA-reductase inhibitor

Act by competitively inhibiting HMG-CoA reductase

It's the first and key rate-limiting enzyme of the cholesterol biosynthetic pathway.


Cholesterol absorption inhibitors

Cholesterol absorption inhibitors reduce the absorption of dietary and biliary cholesterol through the intestines.

Therefore it decreases the amount of intestinal cholesterol that is delivered to the liver.

Reduced levels of cholesterol delivered to the liver results in increased hepatic LDL (low-density lipoprotein) receptor activity.

This leads to increased clearance of LDL cholesterol.

Cholesterol absorption inhibitors are used to treat hyperlipidemia, by lowering LDL cholesterol and total cholesterol.

Fabric acid derivatives

Fabric acid derivatives or fibrates are regarded as broad-spectrum lipid-lowering drugs.

Their main action is to decrease triglyceride levels but they also tend to reduce low-density lipoprotein (LDL) cholesterol levels and help to raise high-density lipoprotein (HDL) cholesterol.

Fibrates appear to activate a protein called peroxisome proliferator-activated receptor alpha (PPAR-alpha).


Top Musculoskeletal Drugs

Muscle relaxants:

Neuromuscular blocking agents work at the neuromuscular junction. There are two types, depolarizing and non-depolarizing.


Top Gastrointestinal Drugs

Gastrointestinal drugs include many different classes of drugs that are used to treat gastrointestinal disorders.

  • 5-aminosalicylates
  • antacids
  • antidiarrheals
  • digestive enzymes
  • functional bowel disorder agents
    • anticholinergics/antispasmodics
    • chloride channel activators
    • guanylate cyclase-C agonists
    • peripheral opioid receptor antagonists
    • peripheral opioid receptor mixed agonists/antagonists
    • serotoninergic neuroenteric modulators
  • gallstone solubilizing agents
  • inflammatory bowel disorder
  • GI stimulants
  • H. pylori eradication agents
  • H2 antagonists
  • laxatives
  • miscellaneous GI agents
  • proton pump inhibitors
  • antiemetic

Types:

Drugs for peptic ulcer

PPI

They block the gastric H,K-ATPase, inhibiting gastric acid secretion. This effect enables healing of peptic ulcers, gastroesophageal reflux disease (GERD), Barrett's oesophagus, and Zollinger-Ellison syndrome.

Histamine H2 antagonists

H2 antagonists block histamine-induced gastric acid secretion from the parietal cells of the gastric mucosa (lining of the stomach).

This suppresses basal and meal-stimulated acid secretion in a dose-dependent manner.

H2 antagonists are used to treating gastroesophageal reflux disease (GERD), gastrointestinal ulcers and other gastrointestinal hypersecretory conditions.

Antiemetic

The main classes of antiemetics are:

  • Dopamine antagonists (eg, metoclopramide, haloperidol, domperidone, levomepromazine, other antipsychotics)
  • Antihistamines (eg, cyclizine, promethazine)
  • Serotonin (5HT3) antagonists (eg, ondansetron, tropisetron, granisetron)
  • others

Laxative

Laxatives can be classified into four main categories:

  • bulk laxatives
  • stimulant laxatives
  • osmotic laxatives
  • stool softeners.
  • Saline osmotic laxative

Antispasmodic

A group of medicines that can help to control some symptoms that arise from the gut (intestines) in particular, gut spasm.

There are two main types, as follows.

  • Antimuscarinics
  • Smooth muscle relaxant

Inflammatory bowel disorder

Inflammatory bowel disease (IBD) is an umbrella term used to describe disorders that involve chronic inflammation of the digestive tract. The goal of inflammatory bowel disease treatment is to reduce inflammation. The treatment includes using :

  • Anti-inflammatory drugs
  • Immune system suppressors
  • Antibiotics
  • Other medications and supplements

Immune system suppressors

These drugs work in a variety of ways to suppress the immune response that releases inflammation-inducing chemicals in the intestinal lining.

Some examples of immunosuppressant drugs include tumour necrosis factor (TNF)-alpha inhibitors, or biologics, works by neutralizing a protein produced by the immune system.

Top 200 Drugs


Top Respiratory Drugs

Respiratory agents is a term used to describe a wide variety of medicines used to relieve, treat, or prevent respiratory diseases such as asthma, chronic bronchitis, chronic obstructive pulmonary disease (COPD), or pneumonia. Drugs for respiratory drugs

  • antiasthmatic combinations
  • antihistamines
  • antitussives
  • bronchodilators
    • adrenergic bronchodilators
    • anticholinergic bronchodilators
    • bronchodilator combinations
    • methylxanthines
  • decongestants
  • expectorants
  • leukotriene modifiers
  • lung surfactants
  • miscellaneous respiratory agents
  • respiratory inhalant products
    • inhaled anti-infectives
    • inhaled corticosteroids
    • mast cell stabilizers
    • mucolytics
  • selective phosphodiesterase-4 inhibitors
  • upper respiratory combinations

Type:

Beta-2 agonist

Activation of β adrenergic receptors leads to relaxation of smooth muscle in the lung, and dilation and opening of the airways

Anticholinergic

These work by binding to muscarinic receptors and blocking the action of acetylcholine.They reduce bronchomotor tone, which effectively leads to bronchodilation

Leukotriene receptor antagonist:

They are are a class of oral medication that is non-steroidal, called LTRAs for short . They may also be referred to as anti-inflammatory bronchoconstriction preventors.

LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways

Histamine H1 Antagonist

The primary mechanism of antihistamine action in the treatment of allergic diseases is competitive antagonism of histamine binding to cellular receptors.

They are present on nerve endings, smooth muscles, and glandular cells.

Corticosteroid

Corticosteroids are classified as either:

  • Glucocorticoids (anti-inflammatory) which suppress inflammation and immunity and assist in the breakdown of fats, carbohydrates, and proteins.
  • Mineralocorticoids (salt retaining) that regulate the balance of salt and water in the body.

Antitussive

Antitussives help your cough by deterring your cough reflex. Antitussive is sometimes used in combination with an expectorant that helps to thin mucus.

Top 200 Drugs


Commonly Anti-glaucoma Drugs

Ophthalmic preparations are agents especially designed to be applied to the eye. They used to treat or diagnose the different eye diseases

Antiglaucoma drugs

Antiglaucoma eye drops help keep the pressure at the right level for you, which reduces the risk of loss of vision.

They include:

  • Alpha agonists
    Reduce the production of fluid in the eye and to improve the flow of fluid out of the eye
  • Beta blockers
    Reduce the production of fluid in the eye.
  • Prostaglandin analogues


Commonly Used Antimicrobial Drugs

Drugs used to treat a microbial infection. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. they include

  1. Antibiotic
  2. Antiviral
  3. Antifungal
  4. Antiparasetic

Types:

Antibiotic

Antibiotics, also known as antibacterials, are medications that destroy or slow down the growth of bacteria

The antibiotics are commonly classified based on the  mechanism of action, chemical structure, or spectrum of activity Antibiotic classification .according to chemical structure

I- naturally producing antimicrobial:

  1. β Lactam antibiotics
  2. Tetracycline group
  3. Rifamycins
  4. Aminoglycoside-aminocyclitol antibiotics
  5. Macrolides
  6. Lincosamides
  7. Streptogramins
  8. Polypeptide antibiotics
  9. Glycopeptide antibiotics
  10. Miscellaneous antibacterial antibiotics
  11. Chloramphenicol
  12. Fusidic acid
  13. Mupirocin (pseudomonic acid A)

II-Synthetic antimicrobial agents

  1. Sulphonamides
  2. Diaminopyrimidine derivatives
  3. Co-trimoxazole
  4. Dapsone
  5. Antitubercular drugs
  6. Nitrofuran compounds
  7. Quinolone antibacterials
  8. Imidazole derivatives
  9. Flucytosine
  10. Synthetic allylamines
  11. Synthetic thiocarbamates
  12. Oxazolidinones

Antiviral

They are medication that destroy or slow down the growth of virus. An antiviral agent must act at one of five basic steps in the viral replication cycle in order to inhibit the virus:

  1. attachment and penetration of the virus into the host cell,
  2. uncoating of virus (e.g., removal of the protein surface and release of the viral DNA or RNA),
  3. synthesis of new viral components by the host cell as directed by the virus DNA,
  4. assembly of the components into new virus,
  5. release of the virus from the host cell.

Antiprotozoal drug

They any agent that kills or inhibits the growth of organisms known as protozoans. Protozoans cause a variety of diseases, including malariaand Chagas' disease. While protozoans typically are microscopic, they are similar to plants and animals in that they are eukaryotes and thus have a clearly defined cell nucleus. This distinguishes them from prokaryotes, such as bacteria. As a result, many of the antibiotics that are effective in inhibiting bacteria are not active against protozoans.

Antifungal

Antifungal medicines are used to treat fungal infections, which most commonly affect skin, hair and nails.

Top 200 Drugs


Commonly Used Hormone Treatment

It is the use of hormones in medical treatment among Top 200 Drugs.

Treatment with hormone antagonists may also be referred to as hormonal therapy or antihormone therapy.

The most general classes of hormone therapy are oncologic hormone therapy. In addition, hormone replacement therapy (for menopause), androgen replacement therapy(ART),  contraceptives and transgender hormone therapy.

Contraceptive

Contain two types of synthetic female hormones estrogen and progestin. These are similar to the estrogen and progesterone normally made by the ovaries.

Top 200 Drugs


Common Anticoagulant Drugs

They are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.

They are used in therapy for thrombotic disorders.

Types

Factor Xa inhibitor

They work by selectively and reversibly blocking the activity of clotting factor Xa, preventing clot formation.

They affect both factor Xa within the blood and within a preexisting clot

Antiplatelet

They decrease platelet aggregation and inhibit thrombus formation

Top 200 Drugs


Miscellaneous Common Drugs

Top 200 Drugs


Drugs for Hypothyroidism

Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone

Vitamins and minerals are nutrients that body needs in small amounts to work properly and stay healthy. There are 13 vitamins—vitamins C, A, D, E, K, and the B vitamins (thiamine, riboflavin, niacin, pantothenic acid, biotin, B6, B12, and folate).

Norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI).Act as a reuptake inhibitor for norepinephrine and epinephrine by blocking the action of the norepinephrine transporter (NET). Atomoxetine is a selective norepinephrine reuptake inhibitor used primarily for therapy of attention deficit hyperactivity disorder

Histone deacetylase inhibitors (HDAC inhibitors) are chemical compounds that inhibit histone deacetylases.

HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are being investigated as possible treatments for cancers parasitic and inflammatory diseases.

Anorexiants are drugs that act on the brain to suppress appetite. They have a stimulant effect on the hypothalamic and limbic regions, which control satiety. Anorexiants are used as therapy for obesity

Stimulate neurons to release or maintain high levels of catecholamines. High levels of these catecholamines tend to suppress hunger signals and appetite.

Anti-manic drug, any drug that stabilizes mood by controlling symptoms of mania, the abnormal psychological state of excitement.

Mania is a severe form of emotional disturbance in which a person is progressively and inappropriately euphoric and simultaneously hyperactive in speech and locomotor behaviour. This is often accompanied by significant insomnia (inability to sleep), excessive talking, extreme confidence, and increased appetite. As the episode builds, the person experiences racing thoughts, extreme agitation, and incoherence, frequently replaced with delusions, hallucinations, and paranoia, and ultimately may become hostile and violent and may finally collapse. In some persons, periods of depression and mania alternate, giving rise to bipolar disorder.

As per FDA regulations any drug that may lead to adverse reactions.

Moreover, ones that might cause serious injury or result in death should be labelled by black box warning.

The number of drugs with black box warning is 81 drugs (40.5%) of 200 most prescribed medicines.


Dosage Forms

The lists also highlight the dosage forms of the top 200 most prescribed drugs.

  • Oral: 166
  • Inhalation: 7
  • Intravenous: 3
  • Intramuscular: 2
  • Injections: 7
  • Liquids: 4
  • Subcutaneous: 4
  • Ophthalmic: 3
  • Nasal: 1
  • Topical: 1
  • Transdermal: 1
  • Vaginal: 1

Biologicals and Chemicals

As per the lists, only 7 (3.5%) of drugs were biologicals among the top 200 most prescribed drugs.

The rest were chemical entities.


Opioids

Five opioids acetaminophen/hydrocodone, tramadol, oxycodone, hydrocodone, and morphine are among the top 200 drugs.

In fact, Acetaminophen/hydrocodone is 1 of the top 10 most prescribed drugs.


Adverse Drug Reactions

Within the top 200 drugs the most common ADRs and their range according to the systems are as following:

Top 200 Drugs


Importance of list:

Pharmacy students and pharmacists should be familiar with prescribed drugs.

That is to deliver optimum pharmacy services to clients.

The question is how many products they need to know.

The lists of 200 prescribed drugs has in fact been used as part of in-house training.

Also to ease ordering of drug stocks at community pharmacies, e.g. Boots the Chemist and some hospitals.

In addition to pharmacy practice, the drug list is also beneficial to other hard sciences, i.e. pharmaceutics and pharmaceutical chemistry.

This list enables students and residents to be more confident and competent before facing actual patients.

It will be handy for pharmacists, researchers and other healthcare professionals interested in developing new strategies for treating patients.


The expiry date of Some drugs:

Top 200 Drugs

Conclusion:

Pharmacists are an integral part of our health care team.

They are also considered the most accessible health care professionals.

The drug list may serve as easy access to ideas for pharmacists.

In addition to researchers and other healthcare professionals interested in developing new strategies for treating patients with various ailments.

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Source: https://fadic.net/top-200-drugs-to-memorize/

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